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Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale
Frontiers of Medicine 2013, Volume 7, Issue 4, Pages 462-476 doi: 10.1007/s11684-013-0270-6
Keywords: drug resistance cancer stem cell checkpoint kinase 1 (CHK1) PF-00477736 lung cancer tumorigenicity
Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott
Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2, Pages 186-195 doi: 10.1007/s11705-015-1540-4
Keywords: RNA splicing gene expression breast cancer DNA damage CHK1
Molecular classification and precision therapy of cancer: immune checkpoint inhibitors
Yingyan Yu
Frontiers of Medicine 2018, Volume 12, Issue 2, Pages 229-235 doi: 10.1007/s11684-017-0581-0
Keywords: molecular classification precision medicine pembrolizumab PD-1/PD-L1 MSI-H
Frontiers of Medicine Pages 805-822 doi: 10.1007/s11684-023-1025-7
Keywords: CTLA-4 PD-1 PD-L1 immune checkpoint blockade (ICB) metabolic reprogramming combined tumor therapeutic
Activation of phagocytosis by immune checkpoint blockade
Chia-Wei Li, Yun-Ju Lai, Jennifer L. Hsu, Mien-Chie Hung
Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 473-480 doi: 10.1007/s11684-018-0657-5
Keywords: CD47 PD-1 PD-L1 immunotherapy TAM phagocytosis macrophage
PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives
Yumeng Wang, Guiling Li
Frontiers of Medicine 2019, Volume 13, Issue 4, Pages 438-450 doi: 10.1007/s11684-018-0674-4
Keywords: PD-1 PD-L1 immune checkpoint blockade antibody immunotherapy cervical cancer
Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice
Yuqin Men,Aizhen Zhang,Liwen Zhang,Yecheng Jin,Zhishuo Wang,Jing Zhao,Xiaolin Yu,Jian Zhang,Jiangang Gao
Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 481-489 doi: 10.1007/s11684-016-0494-3
The tumor suppressor gene liver kinase B1 (LKB1), also called STK11, encodes a serine/threonine kinaseLKB1 plays crucial roles in cell differentiation, proliferation, and polarity.In this study, LKB1 conditional knockout mice (LKB1Pax2 CKO mice) were generated usingLKB1Pax2 CKO mice died perinatally.LKB1 deficiency in LKB1Pax2 CKO mice thus disrupted hair cell planar polarity during
Keywords: LKB1 stereociliary bundles kinocilium planar cell polarity hearing mice
Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy
Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian
Frontiers of Medicine 2019, Volume 13, Issue 1, Pages 32-44 doi: 10.1007/s11684-018-0678-0
Keywords: immune checkpoint companion diagnosis PD-L1 tumor mutation burden immune score
PAK1 is a novel cardiac protective signaling molecule
Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei
Frontiers of Medicine 2014, Volume 8, Issue 4, Pages 399-403 doi: 10.1007/s11684-014-0380-9
We review here the novel cardiac protective effects of the multifunctional enzyme, p21-activated kinase1 (PAK1), a member of a serine/threonine protein kinase family.Despite the large body of evidence from studies in noncardiac tissue indicating that PAK1 activity iskey in the regulation of a number of cellular functions, the role of PAK1 in the heart has only beenWe discuss the anti-adrenergic and antihypertrophic cardiac protective effects of PAK1, as well as its
Keywords: p21-activated kinase 1 (PAK1) heart
Frontiers of Medicine Pages 878-888 doi: 10.1007/s11684-023-0993-y
Keywords: uveal melanoma liver-directed therapy immune checkpoint blockade SIRT anti-PD-1 anti-CTLA-4
The role of CDK1 siRNA interference in cell cycle and cell apoptosis
Hui XIAO PhD, Ming TIAN MM, Junna GE MM, Xin Wei MD, Zhaoming LI MM, Xiaolan LI MS, Deding TAO PhD, Junbo HU MD, Jianping GONG MD,
Frontiers of Medicine 2009, Volume 3, Issue 4, Pages 384-389 doi: 10.1007/s11684-009-0070-1
Keywords: cyclin-dependent kinase1 siRNA interference cell cycle apoptosis
Analysis of GM(1,1)Model and Its Application in Fire Risk Prediction
Chen Zijin,Wang Fuliang,Lu Shouxiang
Strategic Study of CAE 2007, Volume 9, Issue 5, Pages 91-94
Theoretical analysis of grey prediction model GM(1, 1) is present inMonotonicity of predicted value and its variation tendency predicted by GM(1, 1)model is proved.the monotonicity of predicted value and its variation tendency, applicability criterion of GM(1,1) is brought forward.
Keywords: fire forecast GM(1 1) rate of the fire injured
Deng Yunhua
Strategic Study of CAE 2011, Volume 13, Issue 10, Pages 13-18
Keywords: Bohai Liaodong zone JX1-1 geological recognition large oilfield
Federated unsupervised representation learning Research Article
Fengda ZHANG, Kun KUANG, Long CHEN, Zhaoyang YOU, Tao SHEN, Jun XIAO, Yin ZHANG, Chao WU, Fei WU, Yueting ZHUANG, Xiaolin LI,fdzhang@zju.edu.cn,kunkuang@zju.edu.cn
Frontiers of Information Technology & Electronic Engineering 2023, Volume 24, Issue 8, Pages 1181-1193 doi: 10.1631/FITEE.2200268
Keywords: Federated learning Unsupervised learning Representation learning Contrastive learning
Non-equidistant GM(1,1) power model and its application in engineering
Wang Zhengxin,Dang Yaoguo,Liu Sifeng
Strategic Study of CAE 2012, Volume 14, Issue 7, Pages 98-102
Keywords: grey system non-equidistant sequence GM(1 1) power model parameter optimization
Title Author Date Type Operation
Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-like
Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale
Journal Article
protect breast cancer cells from accumulating replication stress by ensuring productive splicing of checkpointkinase 1
Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott
Journal Article
Molecular classification and precision therapy of cancer: immune checkpoint inhibitors
Yingyan Yu
Journal Article
Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms
Journal Article
Activation of phagocytosis by immune checkpoint blockade
Chia-Wei Li, Yun-Ju Lai, Jennifer L. Hsu, Mien-Chie Hung
Journal Article
PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives
Yumeng Wang, Guiling Li
Journal Article
Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice
Yuqin Men,Aizhen Zhang,Liwen Zhang,Yecheng Jin,Zhishuo Wang,Jing Zhao,Xiaolin Yu,Jian Zhang,Jiangang Gao
Journal Article
Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy
Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian
Journal Article
PAK1 is a novel cardiac protective signaling molecule
Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei
Journal Article
Liver-directed treatment is associated with improved survival and increased response to immune checkpoint
Journal Article
The role of CDK1 siRNA interference in cell cycle and cell apoptosis
Hui XIAO PhD, Ming TIAN MM, Junna GE MM, Xin Wei MD, Zhaoming LI MM, Xiaolan LI MS, Deding TAO PhD, Junbo HU MD, Jianping GONG MD,
Journal Article
Analysis of GM(1,1)Model and Its Application in Fire Risk Prediction
Chen Zijin,Wang Fuliang,Lu Shouxiang
Journal Article
geological recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-1
Deng Yunhua
Journal Article
Federated unsupervised representation learning
Fengda ZHANG, Kun KUANG, Long CHEN, Zhaoyang YOU, Tao SHEN, Jun XIAO, Yin ZHANG, Chao WU, Fei WU, Yueting ZHUANG, Xiaolin LI,fdzhang@zju.edu.cn,kunkuang@zju.edu.cn
Journal Article